Origin of the Native Driving Force for Protein Folding
نویسندگان
چکیده
منابع مشابه
Origin of the native driving force for protein folding.
We derive an expression with four adjustable parameters that reproduces well the 20x20 Miyazawa-Jernigan potential matrix extracted from known protein structures. The numerical values of the parameters can be approximately computed from the surface tension of water, water-screened dipole interactions between residues and water and among residues, and average exposures of residues in folded prot...
متن کاملOrigin of Native Driving Force in Protein Folding
We derive an expression with four adjustable parameters that reproduces well the 20×20 MiyazawaJernigan potential matrix extracted from known protein structures. The numerical values of the parameters can be approximately computed from the surface tension of water, water-screened dipole interactions between residues and water and among residues, and average exposures of residues in folded prote...
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Using the Helmholtz decomposition of the vector field of folding fluxes in a two-dimensional space of collective variables, a potential of the driving force for protein folding is introduced. The potential has two components. One component is responsible for the source and sink of the folding flows, which represent respectively, the unfolded states and the native state of the protein, and the o...
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In a statistical approach to protein structure analysis, Miyazawa and Jernigan (MJ) derived a 20 × 20 matrix of inter-residue contact energies between different types of amino acids. Using the method of eigenvalue decomposition, we find that the MJ matrix can be accurately reconstructed from its first two principal component vectors as Mij = C0 + C1(qi + qj) + C2qiqj , with constant C’s, and 20...
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It is well documented that in eukaryotic cells molecules of one protein can be located in several subcellular locations, a phenomenon termed dual targeting, dual localization, or dual distribution. The differently localized identical or nearly identical proteins are termed "echoforms." Our conventional definition of dual targeted proteins refers to situations in which one of the echoforms is tr...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2000
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.84.574